Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection

摘要: Middle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but not readily available. In contrast, nearly all camels in the have been infected with MERS-CoV. Here, we show that sera obtained MERS-immune augment kinetics of MERS-CoV clearance and reduce severity pathological changes lungs, efficacy proportional to titer MERS-CoV-neutralizing serum antibody. IMPORTANCE syndrome, caused by coronavirus, lethal, case fatality rate 35 40%. No specific therapy available, care generally supportive. One promising approach passive administration human or other animals exposed patients. The vast majority of, if all, MERS-CoV, contain high titers antibody virus. this protective delivered either prophylactically therapeutically mice indicating be useful intervention