The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling
作者： Catalina Ribas , Petronila Penela , Cristina Murga , Alicia Salcedo , Carlota García-Hoz
DOI: 10.1016/J.BBAMEM.2006.09.019
关键词:
摘要: G protein-coupled receptor kinases (GRKs) and arrestins are key participants in the canonical pathways leading to phosphorylation-dependent GPCR desensitization, endocytosis, intracellular trafficking resensitization as well modulation of important signaling cascades by GPCR. Novel studies have revealed a phosphorylation-independent desensitization mechanism operating through their RGS-homology (RH) domain recent determination crystal structures GRK2 GRK6 has uncovered interesting details on structure-function relationships these kinases. Emerging evidence indicates that activity GRKs is tightly modulated mechanisms including phosphorylation different interaction with several cellular proteins such calmodulin, caveolin or RKIP. In addition, involved multiple interactions non-receptor (PI3K, Akt, GIT MEK) point novel GRK roles. this article, our purpose describe ever increasing map functional for basis better understand its contribution processes.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(72)
Petra Vatter, Claudia Stoesser, Ines Samel, Peter Gierschik, Barbara Moepps, The variable C-terminal extension of G-protein-coupled receptor kinase 6 constitutes an accessorial autoregulatory domain FEBS Journal. ,vol. 272, pp. 6039- 6051 ,(2005) , 10.1111/J.1742-4658.2005.04995.X
W.J. Koch, J. Inglese, W.C. Stone, R.J. Lefkowitz, The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. Journal of Biological Chemistry. ,vol. 268, pp. 8256- 8260 ,(1993) , 10.1016/S0021-9258(18)53090-8
I. García-Higuera, P. Penela, C. Murga, G. Egea, P. Bonay, J.L. Benovic, F. Mayor, Association of the regulatory beta-adrenergic receptor kinase with rat liver microsomal membranes. Journal of Biological Chemistry. ,vol. 269, pp. 1348- 1355 ,(1994) , 10.1016/S0021-9258(17)42264-2
Suzanne Hagan, Rey Garcia, Amardeep Dhillon, Walter Kolch, Raf Kinase Inhibitor Protein Regulation of Raf and MAPK Signaling Methods in Enzymology. ,vol. 407, pp. 248- 259 ,(2006) , 10.1016/S0076-6879(05)07021-7
Rachel Sterne-Marr, Gurpreet K. Dhami, John J.G. Tesmer, Stephen S.G. Ferguson, Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins. Methods in Enzymology. ,vol. 390, pp. 310- 336 ,(2004) , 10.1016/S0076-6879(04)90020-1
Michele Sallese, Stefania Mariggiò, Etrusca D'Urbano, Luisa Iacovelli, Antonio De Blasi, Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq. Molecular Pharmacology. ,vol. 57, pp. 826- 831 ,(2000) , 10.1124/MOL.57.4.826
LUISA IACOVELLI, MICHELE SALLESE, STEFANIA MARIGGIò, ANTONIO DE BLASI, Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins The FASEB Journal. ,vol. 13, pp. 1- 8 ,(1999) , 10.1096/FASEBJ.13.1.1
Takako Shiina, Ken Arai, Shihori Tanabe, Norihiro Yoshida, Tatsuya Haga, Taku Nagao, Hitoshi Kurose, Clathrin Box in G Protein-coupled Receptor Kinase 2 Journal of Biological Chemistry. ,vol. 276, pp. 33019- 33026 ,(2001) , 10.1074/JBC.M100140200
Raymond B Penn, Alexey N Pronin, Jeffrey L Benovic, Regulation of G Protein-Coupled Receptor Kinases Trends in Cardiovascular Medicine. ,vol. 10, pp. 81- 89 ,(2000) , 10.1016/S1050-1738(00)00053-0
David T. Lodowski, Valerie M. Tesmer, Jeffrey L. Benovic, John J. G. Tesmer, The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs Journal of Biological Chemistry. ,vol. 281, pp. 16785- 16793 ,(2006) , 10.1074/JBC.M601327200