Design of Mononuclear, Binuclear and Polynuclear Molybdenum(VI) Complexes Based on ONO Benzoylacetone Derived Enaminones and their in vitro Biological Activity

摘要: Abstract Molybdenum(VI) complexes of different nuclearity, mononuclear, [MoO2(L1 or 2)(MeOH)]·MeOH (1·MeOH and 2·MeOH), 2)(D)] [D = pyridine, (1a 2a), 3-methylpyridine, (1b 2b) 4-methylpyridine, (1c 2c)], binuclear [{MoO2(L1 2)}2(D)] (D = 4,4′-bipyridine (1d, 1d′ 2d), polynuclear 2)]n (3 4) were synthesized by solution based reactions enaminones (H2L1 = 3-(2-hydroxy-4-methylphenylamino)-1-phenylbut-2-en-1-one; H2L2 = 3-(2-hydroxy-5-methylphenylamino)-1-phenylbut-2-en-1-one) with the dioxobis(acetylacetonato)molybdenum(VI) complex, [MoO2(acac)2]. Reactions mononuclear 1·MeOH 2·MeOH pyridine its derivatives resulted in corresponding complexes. In case [{MoO2(L1)}2(4,4-bpy)] two polymorphic forms are obtained (1d 1d′). The cross-linked transformations when exposed to vapors N-heterocyclic bases have been explored. Crystal molecular structures ten (1·MeOH, 2·MeOH, 1a–d, 1d′, 2b–d) determined single-crystal X-ray diffraction analysis. Enaminone ligands their molybdenum characterized elemental TG analysis, IR NMR spectroscopy screened for vitro cytotoxic antibacterial activities. None tested compounds showed ability against THP-1 HepG2 cell lines. Compounds 1·MeOH, 1b, 2a 3, exhibited weak activity on Moraxella catarrhalis strain while other did not show properties towards Staphylococcus aureus, Enterococcus faecalis Escherichia coli bacteria.