Barrett’s esophagus and Barrett’s carcinoma

摘要: The rise in the incidence of esophageal adenocarcinomas has raised interest precursor lesion Barrett’s esophagus (BE). Carcinogenesis within BE follows a sequence histopathologic changes. Low-grade intraepithelial neoplasia is major risk factor for progression to high-grade (HG-IN) and invasive carcinoma. Other factors are Barrett length prevalence size associated hiatal hernias. Prevention carcinogenesis by medical or surgical acid suppression not been proven effective. Chemoprevention with nonsteroidal anti-inflammatory drugs, as well other molecular-targeted therapies, promising currently under investigation. Endoscopic ablation experimental accompanied severe side effects. surveillance recommended early detection malignant progression. When end point (HG-IN carcinoma) reached, esophagectomy still standard treatment, although limited endoscopic resection can be performed lower morbidity favorable long-term results.