Age-incidence relationships and time trends in cervical cancer in Sweden.

摘要: Age-incidence relationships are informative of carcinogenic mechanisms. These have been previously assessed for cervical squamous cell carcinoma (SCC) but not adenocarcinoma. The aim was to assess by means age-, period- and cohort-specific analyses Poisson regression modelling whether the two types cancer show an age-incidence maximum at a relatively young age, as shown in cross-sectional analyses. Swedish Family-Cancer Database used analyse SCC adenocarcinoma diagnosed years 1958-1996, including total 15,118 1866 cases, respectively. Area residence socio-economic status were included because they risk factors cancer. analysis confirmed incidence ages 35-39 years. data also suggested similar early age curves differed extensively birth cohort. increased substantially groups towards end follow-up. Endometrial vaginal vulvar SCC, which share some with cancer, did maximum. results showed that there decrease around year 1960, almost 10 before organized population screening, probably due introduced opportunistic pap testing. benefits screening observed further decline rates. unique call biological explanations.