An Investigation into the Role of Polymeric Carriers on Crystal Growth within Amorphous Solid Dispersion Systems

摘要: Using phase diagrams derived from Flory-Huggins theory, we defined the thermodynamic state of amorphous felodipine within three different polymeric carriers. Variation in solubility and miscibility materials (using F-H theory) has been identified used to select most suitable carriers for production drug-polymer solid dispersions. With this information, dispersions were manufactured using (HPMCAS-HF, Soluplus, PVPK15) at predefined drug loadings, crystal growth rates these investigated. Crystallization was studied Raman spectral imaging polarized light microscopy. data, examined correlation among several characteristics rate felodipine. An exponential relationship found exist between loading rate. Moreover, all selected dispersion systems viscosity dependent (η(-ξ)). The exponent, ξ, estimated be 1.36 a temperature 80 °C. Values ξ exceeding 1 may indicate strong systems. We argue that elevated exponent value (ξ > 1) is result mixing which leads less fragile system. All investigated displayed an upper critical solution temperature, solid-liquid boundary always higher than spinodal decomposition curve. Furthermore, PVP-FD loadings 0.6 volume ratio, mechanism separation metastable zone driven by nucleation rather liquid-liquid separation.