ETS1-activated SNHG10 exerts oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis.

摘要: BACKGROUND In past few years, long non-coding RNAs (lncRNAs) have been reported to play regulatory roles during cancer progression. LncRNA SNHG10 has explored in several sorts of cancers. However, its detailed role and mechanism are still not well understood glioma. METHODS Expression levels genes were evaluated by RT-qPCR. EdU, TUNEL, sphere formation, wound healing transwell assays appraised the effect on glioma cellular processes. The interaction between molecules was examined ChIP, RIP, RNA pull down luciferase reporter assays. RESULTS High level detected cells. Functional assay confirmed that promoted proliferation, migration, invasion stemness Moreover, miR-532-3p validated bind with expressed at a low Importantly, exerted inhibitory functions Furthermore, it found FBXL19 targeted facilitated cell growth glioma, worked increasing expression through sequestering miR-532-3p. More importantly, ETS1 transcription mediated contribution malignant behaviors cells SNHG10/miR-532-3p/FBXL19 signaling. CONCLUSION transcriptionally activated played an oncogenic sponging up-regulating FBXL19.