Identifying Hypoperfusion in Moyamoya Disease With Arterial Spin Labeling and an [15O]-Water Positron Emission Tomography/Magnetic Resonance Imaging Normative Database

摘要: Background and Purpose- Noninvasive imaging of brain perfusion has the potential to elucidate pathophysiological mechanisms underlying Moyamoya disease enable clinical cerebral blood flow (CBF) select revascularization therapies for patients. We used hybrid positron emission tomography (PET)/magnetic resonance (MRI) technology characterize distribution hypoperfusion in its relationship vessel stenosis severity, through comparisons with a normative database healthy controls. Methods- To image CBF, we acquired [15O]-water PET as reference simultaneously arterial spin labeling (ASL) MRI scans 20 patients 15 age-matched, controls on PET/MRI scanner. The ASL included standard single-delay scan postlabel delay 2.0 s multidelay 5 delays (0.7-3.0s) estimate account transit time CBF quantification. percent volume (determined fifth percentile values control database) was outcome measure logistic regression model that grade location. Results- Logistic showed anterior ( P<0.0001) middle artery territory regions P=0.003) were susceptible hypoperfusion, whereas posterior not. Cortical supplied by arteries MR angiography more than normal P=0.001), but extent not different between mild-moderate versus severe stenosis. Multidelay did perform differently from detecting abnormalities, overestimated P=0.003). Conclusions- This simultaneous study supports use evaluation settings where nuclear medicine is available application automatically identify abnormal