Antitrichomonal activity of 1,3-diaryl-2-propen-1-ones on Trichomonas gallinae

摘要: 1,3-diaryl-2-propen-1-ones were synthesized by the Claisen - Schmidt condensation method. T. gallinae parasites isolated from domestic pigeon cultured in vitro . The susceptibility of gallina was evaluated multi-well plates at 37oC. Four synthetic compounds produced significant antitrichomonal activity against minimal lethal concentrations (MLCs) (produced by) 2\'-hydroxy-4- methoxychalcone, 2\'-hydroxy-2,4\'-dimethoxychalcone, 2\'-hydroxy-4-chlorochalcone, 3,4,4\'-Trimethoxychalcone and 4-hydroxcychalcone 100.0, 0.78, 50.0, 50.0 3.13 µg/ml respectively. results indicate that 2\'-hydroxy-2,4\'-dimethoxychalcone 3 other possess potent However, studies on cytotoxicity effect showed all active chalcones demonstrated a very low haemagglutination titre values ranging between 0.57 – 4.06 suggesting their toxicity profile. Key Words: Trichomonas gallinae, 1,3-diaryl-2-propen-1-ones, Afr. J. Trad. CAM (2004) 1 : 55-62