Effects of long-term fish oil-enriched diet on the sphingolipid metabolism in brain of old rats.
作者： Nataliya A. Babenko , Yaroslava A. Semenova
DOI: 10.1016/J.EXGER.2010.02.010
关键词:
摘要: An increase of the neutral sphingomyelinase (SMase) activity in animal brain at old age is associated with a higher expression inflammatory marker, interleukin-1beta and cognitive decline. Dietary n-3 polyunsaturated fatty acids (n-3 PUFA) are found to exhibit anti-inflammatory effects normalize age- or dementia-related function In paper we investigate ceramide, sphingomyelin (SM) phosphatidylserine (PS) levels hippocampus 3-month-old-32-month-old rats as well correction sphingolipid turnover by means dietetic fish oil PS. To study lipid turnover, [(14)C]-labeled SM palmitic acid were used. The [(14)C]ceramide level significantly increased while those [(14)C]SM, PS decreased aged compared 3-month-old animals. Treatment reduced content SMase 24-month-old animals respect control same age. These results suggest that dietary PUFA can prevent age-dependent abnormalities via rats.
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