Distinct right ventricle remodeling in response to pressure overload in the rat.

摘要: Pulmonary arterial hypertension (PAH), the most serious chronic disorder of pulmonary circulation, is characterized by vasoconstriction and remodeling, resulting in increased afterload on right ventricle (RV). In fact, RV function main determinant prognosis PAH. The frequently used experimental models PAH include monocrotaline- hypoxia-induced PAH, which primarily affect circulation. Alternatively, artery banding (PAB) can be performed to achieve overload without affecting vasculature, allowing researchers determine RV-specific effects their drugs/interventions. this work, using two different degrees constriction, we characterize, full detail, PAB-induced adaptive maladaptive remodeling at 3 wk after PAB surgery. Our results show that application a mild constriction resulted hypertrophy RV, with preserved systolic diastolic function, while severe hypertrophy, chamber dilation dysfunction up isolated cardiomyocyte level. By applying describe, for first time, reliable short-duration model adaptation distinguished We structural functional changes its response moderate better study physiology transition failure, as well new therapies.