Normal Fur Development and Sebum Production Depends on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

摘要: 2-Hydroxylated fatty acid (HFA)-containing sphingolipids are abundant in mammalian skin and believed to play a role the formation of epidermal barrier. Fatty 2-hydroxylase (FA2H), required for synthesis 2-hydroxylated various organs, is highly expressed skin, previous vitro studies demonstrated its HFA human keratinocytes. Unexpectedly, however, mice deficient FA2H did not show significant changes their sphingolipids. Expression murine was restricted sebaceous glands, where it glucosylceramide fraction type II wax diesters. Absence resulted hyperproliferation sebocytes enlarged glands during hair follicle morphogenesis anagen (active growth phase) adult mice. This accompanied by up-regulation factor receptor ligand epigen sebocytes. Loss significantly altered composition physicochemical properties sebum, which often blocked canal, apparently causing delay fiber exit. Furthermore, lacking displayed cycling alopecia with loss telogen. These results underline importance suggest specific gland or sebum lipids, synthesized FA2H, homeostasis.