Vitamin D receptor modulators
作者： Emilio Enrique Bunel , Jianliang Lu , Sunil Nagpal , Tianwei Ma , Robert Peter Gajewski
DOI:
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摘要: The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy D3. These useful for treating bone disease and psoriasis.
lens.org参考文章(33)
Ken Chow, 5-substituted 3-thiophene sulfonamides as antiglaucoma agents ,(1992)
Kurt Schromm, Ernst-Otto Renth, Hans Michael Jennewein, Franz Birke, Christopher John Montague Meade, Ralf Anderskewitz, Benzylamine and phenylethylamine derivatives, processes for preparing the same and their use as medicaments ,(1998)
Sunil Nagpal, Ying Kwong Yee, Vesicant treatment with phenyl-phenyl type vitamin d receptor modulators ,(2004)
William H. Resnik, Harrison's Principles of Internal Medicine ,(1950)
Elizabeth A. Allegretto, Alex M. Nadzan, Marcus F. Boehm, Vitamin d3 mimics ,(1999)
Jianliang Lu, Sunil Nagpal, Tianwei Ma, Robert Peter Gajewski, Charles David Jones, Ying Kwong Yee, Phenyl-furan compounds as vitamin d receptor modulators ,(2004)
Ping Huang, John Ramphal, James Wei, Congxin Liang, Bahija Jallal, Gerald McMahon, Cho Tang, Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorganic & Medicinal Chemistry. ,vol. 11, pp. 1835- 1849 ,(2003) , 10.1016/S0968-0896(03)00039-7
Steve L. Swann, Joel J. Bergh, M. Cindy Farach-Carson, John T. Koh, Rational design of vitamin D3 analogues which selectively restore activity to a vitamin D receptor mutant associated with rickets. Organic Letters. ,vol. 4, pp. 3863- 3866 ,(2002) , 10.1021/OL0266931
Roberto Lin, John H. White, The pleiotropic actions of vitamin D. BioEssays. ,vol. 26, pp. 21- 28 ,(2004) , 10.1002/BIES.10368
Markus Böhm, Thomas A. Luger, Gisela Bonsmann, Disseminated superficial actinic porokeratosis: Treatment with topical tacalcitol Journal of The American Academy of Dermatology. ,vol. 40, pp. 479- 480 ,(1999) , 10.1016/S0190-9622(99)70502-5