A mutant affecting the heavy chain of myosin in Caenorhabditis elegans

摘要: Abstract A set of non-complementing, closely linked, ethyl methanesulphonate-induced mutations in Caenorhabditis elegans specifically affects the structure and function body-wall muscle cells but not pharyngeal musculature. One these mutations, e675, is semidominant results production a new protein about 203,000 molecular weight addition to normal myosin at 210,000 Mr. The abnormal polypeptide chain structurally very similar heavy when maps iodinated peptides are compared. E675 mutant shows clear relation between defective movement, disruption structure, defect chains. altered synthesized heterozygotes, suggesting that e675 mutation either structural gene for or cis acting control element. hypothesis there two classes within same discussed.