Polymorphic forms of human ADP‐ribosyltransferase‐1
作者： Masoud Yadollahi-Farsani , Panagiotis Kefalas , Barbara A. Saxty , John MacDermot
DOI: 10.1046/J.1432-1327.1999.00368.X
关键词:
摘要: Full length cDNA encoding ADP-ribosyltransferase-1 (ART1) was generated from human skeletal muscle. A single base variation the published sequence observed (C770-->T), and established as a polymorphism by screening of population 50 Caucasians. The predicted nonconservative substitution Leu for Pro at codon 257. Cell lines with stable doxycycline-inducible expression two polymorphic forms ART1 were Chinese hamster V79 cells, exploited in studies to compare activities ART1-Pro257 ART1-Leu257. results revealed no differences capacity phosphoinositide-specific phospholipase C cleave isoforms plasma membrane. Furthermore, capacities ART1-Leu257 ADP-ribosylate agmatine or fibroblast growth factor-2 similar. Differences catalytic however, identified when measurements made their membrane-associated proteins on surface cells. Protein(s) molecular mass 80-110 kDa more extensively ADP-ribosylated than ART1-Leu257, accordance Vmax (59.5 +/- 5.5 37.0 3.0) Km values (12.5 4.5 5.0 1. 9) respectively.
sci-hub.se 参考文章(17)
E Nemoto, G Dennert, Y Yu, Cell surface ADP-ribosyltransferase regulates lymphocyte function-associated molecule-1 (LFA-1) function in T cells. Journal of Immunology. ,vol. 157, pp. 3341- 3349 ,(1996)
A Zolkiewska, J Moss, Integrin alpha 7 as substrate for a glycosylphosphatidylinositol-anchored ADP-ribosyltransferase on the surface of skeletal muscle cells. Journal of Biological Chemistry. ,vol. 268, pp. 25273- 25276 ,(1993) , 10.1016/S0021-9258(19)74388-9
E. Nemoto, G. Dennert, Jin Wang, Regulation of CTL by ecto-nictinamide adenine dinucleotide (NAD) involves ADP-ribosylation of a p56lck-associated protein. Journal of Immunology. ,vol. 156, pp. 2819- 2827 ,(1996)
Mikako Tsuchiya, Makoto Shimoyama, Target protein for eucaryotic arginine-specific ADP-ribosyltransferase. Molecular and Cellular Biochemistry. ,vol. 138, pp. 113- 118 ,(1994) , 10.1007/978-1-4615-2614-8_15
IKEZAWA, Bacterial PIPLCs-unique properties and usefulness in studies on GPI anchors. Cell Biology International Reports. ,vol. 15, pp. 1115- 1131 ,(1991) , 10.1016/0309-1651(91)90059-R
Ian J. Okazaki, Anna Zolkiewska, Maria S. Nightingale, Joel Moss, Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases Biochemistry. ,vol. 33, pp. 12828- 12836 ,(1994) , 10.1021/BI00209A014
Francois Vallette, Emmanuelle Mege, Allison Reiss, Milton Adesnik, Construction of mutant and chimeric genes using the polymerase chain reaction Nucleic Acids Research. ,vol. 17, pp. 723- 733 ,(1989) , 10.1093/NAR/17.2.723
A. Zolkiewska, M. S. Nightingale, J. Moss, Molecular characterization of NAD: arginine ADP-ribosyltransferase from rabbit skeletal muscle Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 11352- 11356 ,(1992) , 10.1073/PNAS.89.23.11352
Masoud Yadollahi-Farsani, Nigel J. Gooderham, Donald S. Davies, Alan R. Boobis, ACCELERATED PAPER: Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus Carcinogenesis. ,vol. 17, pp. 617- 624 ,(1996) , 10.1093/CARCIN/17.4.617
Michael A. J. Ferguson, Alan F. Williams, Cell-Surface Anchoring of Proteins via Glycosyl-Phosphatidylinositol Structures Annual Review of Biochemistry. ,vol. 57, pp. 285- 320 ,(1988) , 10.1146/ANNUREV.BI.57.070188.001441