Surface functionalization via PEO coating and RGD peptide for nanostructured titanium implants and their in vitro assessment
作者： Evgeny V. Parfenov , Lyudmila V. Parfenova , Grigory S. Dyakonov , Ksenia V. Danilko , Veta R. Mukaeva
DOI: 10.1016/J.SURFCOAT.2018.10.068
关键词:
摘要: Abstract This research follows a biomimetic approach for implant surface design, and it concerns functionalization nanostructured Ti Grade 4 with composite coating obtained by plasma electrolytic oxidation (PEO) organic pore filler of integrin-active RGD containing peptide (Arg-Gly-Asp-Cys). It was shown that nanostructuring via ECAP-C technique almost two-fold improves its mechanical strength; also, the depassivates surface, both PEO coated uncoated. The on nano-Ti contains 2–3% more biocompatible elements, amorphous bio-crystalline phases. linked to phosphonate groups allowing deposition dipping method; presence in pores proven EIS. For vitro tests, fibroblasts were used; gives 43% increase number cells compared CG-Ti + PEO; combination 45% nano-Ti, 66% CG-Ti. Therefore, this contributes development implants having high strength providing improved cell proliferation.
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