Tracking plasma cell differentiation and survival

摘要: Plasma cells play a crucial role for the humoral immune response as they represent body's factories antibody production. The differentiation from B cell into plasma is controlled by complex transcriptional network and happens within secondary lymphoid organs. Based on their lifetime, two types of secreting can be distinguished: Short-lived are located in extrafollicular sites organs such lymph node medullary cords splenic red pulp. A fraction plasmablasts migrate to bone marrow where become long-lived cells. Bone reside special microanatomical environments termed survival niches, which provide factors promoting longevity. Reticular stromal producing chemokine CXCL12, known attract but also promote survival, maintenance these niches. In addition, hematopoietic contributing niches providing other soluble factors. Here, we review current knowledge involved differentiation, localization migration. We give an overview what regarding long lived marrow.