ACTIONS OF THE SYMPATHOMIMETIC BRONCHODILATOR, TRIMETOQUINOL (AQL 208) ON THE CARDIAC, RESPIRATORY AND SKELETAL MUSCLE SYSTEMS IN THE ANAESTHETIZED CAT, AND ON CAT ISOLATED ATRIAL AND TRACHEAL PREPARATIONS

摘要: SUMMARY 1. The actions of the sympathomimetic bronchodilator trimetoquinol (AQL 208) have been compared with those laevoisoprenaline on cardiac, respiratory and skeletal muscle systems cat under chloralose anaesthesia, isolated atrial tracheal preparations. 2. Trimetoquinol injected intravenously ranged in potency from two to four times less potent about more than different vivo experiments. Despite such wide variations absolute mean effective doses both vitro studies were not significantly (P>0.05) laevoisoprenaline. 3. effect soleus is considered be analogous tremor that often occurs man, results suggest systemic administration may produce as an unwanted side some patients. 4. Trimetoquinol, cat, shows no evidence selectivity for β-adreno-receptors tissues reported it other species. It suggested β-receptors are clearly differentiated they resemble man closely do