Effect of some antiestrogens and aromatase inhibitors on androgen induced sexual behavior in castrated male rats
作者： C Beyer , G Morali , F Naftolin , K Larsson , G Perez-Palacios
DOI: 10.1016/0018-506X(76)90040-4
关键词:
摘要: Abstract The effect of antiestrogens (MER-25, ICI-46474, and cis-clomiphene) aromatase inhibitors (5-α-androstanedione, metopirone, aminoglutethimide) on androgen induced copulatory behavior was tested in sexually inexperienced castrated male tats. Daily injections 1 mg testosterone (T) for 21 days sexual activity most subjects (61% mounting). pretreatment with MER-25 or cis-clomiphene at three dose levels did not block the behavioral response to T. ICI-46474 high level (1 mg/kg) elicited a significant depressory T treated rats. A single injection 6 propionate (TP) mounting 56% rats within 120 hr. Treatment metopirone 5 α-androstanedione (injections every 12 hr 96 hr) inhibit TP. By contrast, aminoglutethimide (5 15 abolished androgen.
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sci-hub.se 参考文章(25)
William G. Luttge, Effects of anti-estrogens on testosterone stimulated male sexual behavior and peripheral target tissues in the castrate male rat ☆ ☆☆ Physiology & Behavior. ,vol. 14, pp. 839- 846 ,(1975) , 10.1016/0031-9384(75)90079-7
GeorgeL. Foss, CLINICAL ADMINISTRATION OF ANDROGENS The Lancet. ,vol. 233, pp. 502- 504 ,(1939) , 10.1016/S0140-6736(00)74069-4
William G Luttge, Nicholas R Hall, Differential effectiveness of testosterone and its metabolites in the induction of male sexual behavior in two strains of albino mice Hormones and Behavior. ,vol. 4, pp. 31- 43 ,(1973) , 10.1016/0018-506X(73)90014-7
C Beyer, K Larsson, G Pérez-Palacios, G Morali, Androgen structure and male sexual behavior in the castrated rat Hormones and Behavior. ,vol. 4, pp. 99- 108 ,(1973) , 10.1016/0018-506X(73)90020-2
C. GILES, K. GRIFFITHS, INHIBITION OF THE AROMATIZING ACTIVITY OF HUMAN PLACENTA BY SU 4885 Journal of Endocrinology. ,vol. 28, pp. 343- 344 ,(1964) , 10.1677/JOE.0.0280343
C Beyer, L de la Torre, K Larsson, G Pérez-Palacios, Synergistic actions of estrogen and androgen on the sexual behavior of the castrated male rabbit. Hormones and Behavior. ,vol. 6, pp. 301- 306 ,(1975) , 10.1016/0018-506X(75)90016-1
Karel Horky, Otto Kuchel, Lubos Stárka, Inge Gregorová, Effect of aminoglutethimide on extraglandular metabolism of exogenous testosterone Metabolism. ,vol. 20, pp. 331- 336 ,(1971) , 10.1016/0026-0495(71)90118-1
J. W. ROSS, D. C. PAUP, M. BRANT-ZAWADZKI, J. R. MARSHALL, R. A. GORSKI, Effects of cis- and trans-clomiphene in the induction of sexual behavior. Endocrinology. ,vol. 93, pp. 681- 685 ,(1973) , 10.1210/ENDO-93-3-681
G MORALI, Testosterone, androstenedione, and androstenediol: Effects on the initiation of mating behavior of inexperienced castrated male rats Hormones and Behavior. ,vol. 5, pp. 103- 110 ,(1974) , 10.1016/0018-506X(74)90011-7
K Larsson, P Södersten, C Beyer, Sexual behavior in male rats treated with estrogen in combination with dihydrotestosterone Hormones and Behavior. ,vol. 4, pp. 289- 299 ,(1973) , 10.1016/0018-506X(73)90028-7