Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Heidi Hahn, Leszek Wojnowski, Georgina Miller, Andreas Zimmer, The patched signaling pathway in tumorigenesis and development: lessons from animal models. Journal of Molecular Medicine. ,vol. 77, pp. 459- 468 ,(1999) , 10.1007/S001099900018

Heidi Hahn, Carol Wicking, Peter G Zaphiropoulos, Mae R Gailani, Susan Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg, Anne Birgitte Unden, Susan Gillies, Kylie Negus, Ian Smyth, Carolyn Pressman, David J Leffell, Bernard Gerrard, Alisa M Goldstein, Michael Dean, Rune Toftgard, Georgia Chenevix-Trench, Brandon Wainwright, Allen E Bale, Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome Cell. ,vol. 85, pp. 841- 851 ,(1996) , 10.1016/S0092-8674(00)81268-4

Chi Chung Hui, Masato Nakafuku, Hisato Kondoh, Hiroshi Sasaki, A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro Development. ,vol. 124, pp. 1313- 1322 ,(1997) , 10.1242/DEV.124.7.1313

Baolin Wang, John F Fallon, Philip A Beachy, Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb Cell. ,vol. 100, pp. 423- 434 ,(2000) , 10.1016/S0092-8674(00)80678-9

Andreas von Deimling, Carol Wicking, Georgia Chenevix-Trench, Frank Berthold, Torsten Pietsch, Helmut K. Wolf, Otmar D. Wiestler, Brandon Wainwright, Bettina Henk, Steffen Albrecht, Anke Koch, Andreas Waha, Jörg Tonn, Nicole Schmandt, Jürgen Kraus, Nils Sörensen, Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched Cancer Research. ,vol. 57, pp. 2085- 2088 ,(1997)

Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. Cold Spring Harbor Symposia on Quantitative Biology. ,vol. 62, pp. 191- 204 ,(1997) , 10.1101/SQB.1997.062.01.025

Mike Rigney, Yvonne Lange, Theodore L. Steck, Jin Ye, Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. Journal of Lipid Research. ,vol. 40, pp. 2264- 2270 ,(1999) , 10.1016/S0022-2275(20)32101-5

Corey Raffel, Benjamin Alderete, Deanne Hebrink, C. David James, Robert B. Jenkins, Daniel W. Fults, Lori Frederick, Sporadic Medulloblastomas Contain PTCH Mutations Cancer Research. ,vol. 57, pp. 842- 845 ,(1997)

Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh, Anne Ryan, Qimin Gu, Chaohui Zhang, Jeannette M. Bonifas, Ching-Wan Lam, Mary Hynes, Audrey Goddard, Arnon Rosenthal, Ervin H Epstein, Frederic J. de Sauvage, Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. ,vol. 391, pp. 90- 92 ,(1998) , 10.1038/34201

Guido Reifenberger, Marietta Wolter, Julia Reifenberger, Mosaad Megahed, Peter Lichter, Ruthild G. Weber, Thomas Ruzicka, Missense Mutations in SMOH in Sporadic Basal Cell Carcinomas of the Skin and Primitive Neuroectodermal Tumors of the Central Nervous System Cancer Research. ,vol. 58, pp. 1798- 1803 ,(1998)