The potential origin of glioblastoma initiating cells.

摘要: Despite intensive clinical and laboratory research effort, Glioblastoma remains the most common invariably lethal primary cancer of central nervous system. The identification stem cell lineage-restricted progenitor populations within adult human brain in conjunction with discovery stem-like cells derived from gliomas which are themselves tumorigenic have been shown to properties self-renewal multipotency, has led hypothesis that this population may represent glioma initiating cells. Extensive characterizing anatomic distribution phenotype neural brain, genetic underpinnings needed for malignant transformation ultimately lead cellular origin glioblastoma. Defining disease provide new therapeutic targets modalities finally altering an otherwise bleak outcome patients