Genetic and Functional Relationships between MHC and NK Receptor Genes
作者： John Trowsdale
DOI: 10.1016/S1074-7613(01)00197-2
关键词:
摘要: HLA class I and NK receptors are encoded within dense clusters of immune loci. The MHC, at 6p21.3, the complex containing KIR loci, 19q13.4, both feature variation in number genes, as well sequence polymorphism. In addition to T cell receptors, several variable I-related molecules interact with polymorphic receptors. Some lectin-related receptor 12p13.1, also have ligands belonging extended family. expanding sequences their some which evolved recently, reveal further complexity recognition disease.
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