Carcinogenicity of nickel compounds in animals.

摘要: A total of 18 nickel compounds were tested for carcinogenicity in male Fischer rats by a single i.m. injection at equivalent dosages (14 mg Ni/rat). Within two years, the following incidences sarcomas occurred site: subsulfide (alpha Ni3S2), 100%, crystalline monosulfide (beta NiS), 100%; ferrosulfide (Ni4FeS4), oxide (NiO), 93%; subselenide (Ni3Se2), 91%; sulfarsenide (NiAsS), 88%; disulfide (NiS2), 86%; subarsenide (Ni5AS2), 85%; dust, 65%; antimonide (NiSb), 59%; telluride (NiTe), 54%; monoselenide (NiSe), 50%; (Ni11AS8), amorphous (NiS), 12%; chromate (NiCrO4), 6%; monoarsenide (NiAs), 0%; titanate (NiTiO3), 0%, ferronickel alloy (NiFe1.6), 84 vehicle controls, 0%. Distant metastases found 109 180 sarcoma-bearing (61%). The nickel-induced included rhabdomyosarcomas, 52%, fibrosarcomas, 18%, undifferentiated sarcomas, 13%, osteosarcomas, 8%, and miscellaneous unclassified 9%. Kendall's rank-correlation test showed that carcinogenic activities correlated (p = 0.02) with their mass-fractions, but not dissolution half-times rat serum or renal cytosol, phagocytic indices peritoneal macrophages vitro. Rank-correlation less than 0.0001) was between potencies to induce erythrocytosis rats. discovery particulate are physical property, namely mass-fraction, may help elucidate mechanisms carcinogenesis; observation stimulation erythropoiesis is activity provides new vivo screening use determining risk compounds.