Protease Inhibitor and Cholinergic System in Alzheimer’s Disease
作者： Shigenobu Nakamura , Seigo Tanaka , Wataru Araki , Teruyuki Tsuji , Shingo Kawashima
DOI: 10.1007/978-1-4684-5844-2_8
关键词:
摘要: The level of mRNA for an amyloid precursor (APP770) containing a Kunitz-type trypsin inhibitor (PI) is elevated in the autopsied Alzheimer brain.1 However, physiological significance augumented APP770 production has not been clarified thus far.
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V. P. Whittaker, E. G. Gray, The isolation of nerve endings from brain: An electron microscopic study of cell fragments derived by homogenization and centrifugation Journal of Anatomy. ,vol. 96, pp. 79- 88 ,(1962)
S G Younkin, C Rosenstein, P L Collins, T L Rosenberry, Cellular localization of the molecular forms of acetylcholinesterase in rat diaphragm. Journal of Biological Chemistry. ,vol. 257, pp. 13630- 13637 ,(1982) , 10.1016/S0021-9258(18)33494-X
S. Nakamura, S. Kawashima, S. Nakano, T. Tsuji, W. Araki, Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormal localization and solubilization. Journal of Neural Transmission-supplement. ,vol. 30, pp. 13- 23 ,(1990) , 10.1007/978-3-7091-3345-3_2
Robert G. Martin, Bruce N. Ames, A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures Journal of Biological Chemistry. ,vol. 236, pp. 1372- 1379 ,(1961) , 10.1016/S0021-9258(18)64180-8
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Carl D. Johnson, Richard L. Russell, A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations Analytical Biochemistry. ,vol. 64, pp. 229- 238 ,(1975) , 10.1016/0003-2697(75)90423-6
M-Marsel Mesulam, M. Asuncion Morán, Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease Annals of Neurology. ,vol. 22, pp. 223- 228 ,(1987) , 10.1002/ANA.410220206
Kunio Koshimura, Tomonobu Kato, Ikuo Tohyama, Shigenobu Nakamura, Masakuni Kameyama, Qualitative abnormalities of choline acetyltransferase in Alzheimer type dementia Journal of the Neurological Sciences. ,vol. 76, pp. 143- 150 ,(1986) , 10.1016/0022-510X(86)90164-4
Nobuya Kitaguchi, Yasuyuki Takahashi, Yasuo Tokushima, Satoshi Shiojiri, Hirataka Ito, Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity Nature. ,vol. 331, pp. 530- 532 ,(1988) , 10.1038/331530A0
Seigo Tanaka, Satoshi Shiojiri, Yasuyuki Takahashi, Nobuya Kitaguchi, Hirataka Ito, Masakuni Kameyama, Jun Kimura, Shigenobu Nakamura, Kunihiro Ueda, Tissue-specific expression of three types of β-protein precursor mRNA: Enhancement of protease inhibitor-harboring types in Alzheimer's disease brain Biochemical and Biophysical Research Communications. ,vol. 165, pp. 1406- 1414 ,(1989) , 10.1016/0006-291X(89)92760-5