Pulmonary targeting of nanoparticle drug matrices.

摘要: Abstract Background: Nanoparticle drug matrices using lipids or liposomes, with diameters of 40–300 nm, have recently been developed to encapsulate drugs like Insulin, Budesonide, and Rifampicin for pulmonary delivery raising interest in their regional lung deposition. Methods: Lung deposition has so far modeled a one-dimensional transport equation, without moving airway boundaries, lumped term particle diffusion, sedimentation, impaction. Here, two-dimensional model an explicit treatment radial the primary mechanism nanoparticle Regional was calculated Weibel's whole geometry during normal breathing medical inhalation cycles. Conclusions: Model predictions agree well measurements total particles 10 nm 10 μm, earlier models incorporating boundaries aerosol dynamics, reported l...