Regulation of human THP-1 macrophage polarization by Trichinella spiralis.

摘要: Trichinella spiralis is a foodborne zoonotic nematode, which causes trichinellosis. During the infection, parasite evades host immune responses by direct and indirect (through excretory-secretory products) contact with cells. One of main targets for immunomodulation induced helminths are macrophages. In this study, we examined whether different stages T. can affect polarization human THP-1 Co-culture adult stage cells in without LPS addition had significant impact on TNFα levels. Interestingly, settings LPS, levels IL-1β significantly increased newborn larvae (NBL) but not muscle (ML). While tested ESP products to compare its effect whole ML parasite, detect an increase pro-inflammatory cytokines like no conditions. Whereas, suppressed inflammatory response measured IL-1β, TNFα, IL-6 anti-inflammatory IL-10 compared control. Our findings indicate potential propose signaling pathways might be engaged mechanism how