Benzylamine and methylamine, substrates of semicarbazide-sensitive amine oxidase, attenuate inflammatory response induced by lipopolysaccharide.

摘要: Current evidence indicates that semicarbazide-sensitive amine oxidase (SSAO) substrates possess insulin-mimic effect, which was thought to play an anti-inflammatory role. The purpose of the present study determine whether SSAO benzylamine (BZA) and methylamine (MA) attenuate inflammatory response induced by lipopolysaccharide (LPS). BALB/c mice peritoneal macrophages (PMs) express RAW264.7 mouse do not were used in vitro studies. Experimental given BZA or MA through intraperitoneal injection before LPS challenge. results showed treatment significantly reduced LPS-induced pro-inflammatory mediators (nitric oxide, TNF-α) production, expression inducible nitric oxide synthase (iNOS) cyclooxygenase (COX)-2, glucose consumption murine PMs, but cell line. metabolites catalyzed SSAO, hydrogen peroxide, formaldehyde, benzaldehyde could also decrease TNF-α iNOS COX-2 expression, vitro. In addition, administration plasma liver lung, transient hyperglycemia chronic hypoglycemia. These findings indicated might be involved effects. responsible for Moreover, useful normalization disposal during endotoxemia.