Theoretical insights into the origin of signal-induced calcium oscillations

摘要: Publisher Summary This chapter discusses the origin of signal-induced calcium oscillations. In a variety cells, stimulation by an external signal triggers train intracellular spikes. The steady-state concentration sequestered can readily be obtained setting resulting algebraic equation equal to zero. A physically acceptable steady state will exist as long maximum release rate is sufficiently larger than pumping rate. waveform oscillations predicted model for cytosolic resembles that spikes observed number cells stimulated signals. particular, rise in preceded rapid acceleration starts from basal level. pattern, which reminiscent pacemaker potential autonomous spiking nerve and muscle has been epithelial histamine. store have sawtooth appearance.