Mitochondrial Function in Allergic Disease.

摘要: The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link the diverse phenotypes of these interlinked morbidities. scope this review is to highlight cellular mechanisms, epidemiology environmental allergens influencing function its importance in allergy asthma. We briefly also consider potential mitochondria-targeted therapies prevention cure. has shown be linked dysfunction. Environmental pollutants observed cause dysfunction, primarily by inducing oxidative stress ROS production. Malfunctioning mitochondria change bioenergetics cell profile favour systemic inflammation, which drives all three types Given existing experimental evidence, approaches targeting (e.g. antioxidant therapy replacement) being conducted relevant disease models—with some progressing towards clinical trials, making focus translational asthma, syndrome.