Acute intoxication due to ibuprofen overdose.

摘要: A male patient ingested a single overdose of ibuprofen (greater than 20 g). The serum levels were 185 mg/L (897 mumol/L) and 51.6 (250 at ten hours 67 hours, respectively, after ingestion. There was also an accumulation metabolites (2-carboxyibuprofen 2-hydroxyibuprofen) in the plasma. became unresponsive developed severe metabolic acidosis, acute renal failure, liver-cell injury, cholestasis, thrombocytopenia. Although his course complicated by respiratory hypotension, upper gastrointestinal tract bleeding, had complete resolution multiple organ failure.