Laminin receptor on platelets is the integrin VLA-6.
作者： Arnoud Sonnenberg , Piet W. Modderman , Frans Hogervorst
DOI: 10.1038/336487A0
关键词:
摘要: Adhesion of platelets to the subendothelial matrix an injured vessel wall is essential step in triggering formation a haemostatic plug. Fibronectin, collagen and laminin are three major components which support platelet adhesion. Receptors for fibronectin have been identified on included integrin family. Here we report that adhesion inhibited by rat monoclonal antibody against family member, VLA-6. This does not affect fibrinogen, or type I III collagen. Binding require activation cell-attachment peptides. Platelet supported Mn2+, Co2+ Mg2+, but Ca2+, Zn2+ Cu2+. cation preference distinct from characteristic other platelet-adhesive glycoproteins.
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sci-hub.se 参考文章(29)
D. Edgar, R. Timpl, H. Thoenen, The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival. The EMBO Journal. ,vol. 3, pp. 1463- 1468 ,(1984) , 10.1002/J.1460-2075.1984.TB01997.X
Herve Lesot, Uwe Kühl, Klaus von der Mark, Isolation of a laminin-binding protein from muscle cell membranes The EMBO Journal. ,vol. 2, pp. 861- 865 ,(1983) , 10.1002/J.1460-2075.1983.TB01514.X
EF Plow, RP McEver, BS Coller, VL Jr Woods, GA Marguerie, MH Ginsberg, Related Binding Mechanisms for Fibrinogen, Fibronectin, von Willebrand Factor, and Thrombospondin on Thrombin-Stimulated Human Platelets Blood. ,vol. 66, pp. 724- 727 ,(1985) , 10.1182/BLOOD.V66.3.724.724
FG Giancotti, LR Languino, A Zanetti, G Peri, G Tarone, E Dejana, Platelets express a membrane protein complex immunologically related to the fibroblast fibronectin receptor and distinct from GPIIb/IIIa. Blood. ,vol. 69, pp. 1535- 1538 ,(1987) , 10.1182/BLOOD.V69.5.1535.1535
G.A. Marguerie, T.S. Edgington, E.F. Plow, Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. Journal of Biological Chemistry. ,vol. 255, pp. 154- 161 ,(1980) , 10.1016/S0021-9258(19)86278-6
L K Jennings, D R Phillips, Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex. Journal of Biological Chemistry. ,vol. 257, pp. 10458- 10466 ,(1982) , 10.1016/S0021-9258(18)34040-7
M E Hemler, C Crouse, Y Takada, A Sonnenberg, Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. Journal of Biological Chemistry. ,vol. 263, pp. 7660- 7665 ,(1988) , 10.1016/S0021-9258(18)68549-7
A. Sonnenberg, H. Janssen, F. Hogervorst, J. Calafat, J. Hilgers, A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody. Journal of Biological Chemistry. ,vol. 262, pp. 10376- 10383 ,(1987) , 10.1016/S0021-9258(18)61123-8
T J Kunicki, D J Nugent, S J Staats, R P Orchekowski, E A Wayner, W G Carter, The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex. Journal of Biological Chemistry. ,vol. 263, pp. 4516- 4519 ,(1988) , 10.1016/S0021-9258(18)68811-8
Jeannette Graf, Yukihide Iwamoto, Makoto Sasaki, George R. Martin, Hynda K. Kleinman, Frank A. Robey, Yoshihiko Yamada, Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding Cell. ,vol. 48, pp. 989- 996 ,(1987) , 10.1016/0092-8674(87)90707-0