On neuronal and glial differentiation of a pluripotent stem cell line, RT4-AC: a branch determination.

摘要: Publisher Summary The development of eukaryotes is the result a series hierarchical or nonhierarchical branchings precursor cells (or pluripotent stem cells). Here, branching implies that predetermined order segregation cell types exists; means from not fixed, but more less random (stochastic). Nonhierarchical has been observed in certain systems. In this chapter, term “maturation” used to describe cases which terminal express overt differentiation properties response external agents, often without division. Under maturation conditions, majority homogeneous population responds an agent and expresses properties. Detailed studies neural as well other characteristics reveal clear-cut neuronal glial tumorigenicity among different derivative upon type conversion. system, (RT4-AC) some both systematic consistent these remarkable clear phenomenon alludes fundamental aspect (branch determination), therefore worthy detailed on its mechanism. This chapter also observes differential maturational responses (RT4-B, RT4-D, RT4-E) dibutyryl-CAMP (dbcAMP). Based study discusses several points about determination