Recurrence of Bacterial Vaginosis Is Significantly Associated With Posttreatment Sexual Activities and Hormonal Contraceptive Use

作者: C. S. Bradshaw , L. A. Vodstrcil , J. S. Hocking , M. Law , M. Pirotta

DOI: 10.1093/CID/CIS1030

关键词:

摘要: Background. Bacterial vaginosis (BV) recurrence following recommended therapies is common yet whether due to persistent infection or re-infection unknown. Our aim was determine behaviours associated with BV in women enrolled a randomized-controlled trial.Methods. Symptomatic 18-50 year old females (>/=3Amsels criteria and Nugent score (NS)=4-10) were 3-arm randomised double-blind placebo-controlled trial at Melbourne Sexual Health Centre Australia 2009-10. 450 participants received 7-days of oral metronidazole equally to: vaginal-clindamycin lactobacillus vaginal-probiotic vaginal-placebo completed questionnaire. At 123 & 6-months self-collected vaginal smears questionnaires. Primary endpoint NS=7-10. Cox regression used estimate hazard ratios (HR) for risk baseline longitudinal characteristics allowing repeated measures from stratifying treatment.Results. 404 (90%) who provided post-randomization data included analyses. Cumulative 6-month 28% (95%CI 24-33%) not treatment. After adjustment frequency sex age having the same pre/post-treatment regular sexual partner(RSP) (Adjusted HR=1.9;95%CI 1.2-3.0) inconsistent condom use (AHR=1.9;1.0-3.3) being born outside (AHR=1.5;1.0-2.1); an oestrogen-containing contraceptive protective (AHR=0.5;0.3-0.8).Conclusions. significantly increased by remaining RSP halved contraceptives. Behavioural practices appear play significant role modifying effectiveness antibiotic treatment BV. These findings have implications clinical practice.

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