Immunological and Virological Benefits Resulted from Short-Course Treatment during Primary HIV Infection: A Meta-Analysis

作者: Jingjing Chen , Xiaoxu Han , Minghui An , Jing Liu , Junjie Xu

DOI: 10.1371/JOURNAL.PONE.0082461

关键词:

摘要: Objectives To assess the potential immunological and virological effects that result from short-course antiretroviral treatment during primary HIV infection (PHI). And to investigate whether initiation time, duration follow-up time after interruption would affect these post-treatment immunovirological outcomes.

参考文章(33)
Loïc Desquilbet, Cécile Goujard, Christine Rouzioux, Martine Sinet, Christiane Deveau, Mairie-Laure Chaix, Daniel Séréni, Faroudy Boufassa, Jean-François Delfraissy, Laurence Meyer, Does transient HAART during primary HIV-1 infection lower the virological set-point? AIDS. ,vol. 18, pp. 2361- 2369 ,(2004)
Kaldor J, Porter K, Lampe Fc, Phillips An, Kinloch-de Loes S, Law M, Effect of transient antiretroviral treatment during acute HIV infection: comparison of the Quest trial results with CASCADE natural history study. Antiviral Therapy. ,vol. 12, pp. 189- 193 ,(2007)
C Koegl, , E Wolf, N Hanhoff, H Jessen, K Schewe, M Rausch, J Goelz, A Goetzenich, H Knechten, H Jaeger, Treatment during primary HIV infection does not lower viral set point but improves CD4 lymphocytes in an observational cohort. European Journal of Medical Research. ,vol. 14, pp. 277- 283 ,(2009) , 10.1186/2047-783X-14-7-277
Eric S. Rosenberg, Marcus Altfeld, Samuel H. Poon, Mary N. Phillips, Barbara M. Wilkes, Robert L. Eldridge, Gregory K. Robbins, Richard T. D'Aquila, Philip J. R. Goulder, Bruce D. Walker, Immune control of HIV-1 after early treatment of acute infection Nature. ,vol. 407, pp. 523- 526 ,(2000) , 10.1038/35035103
Joseph J. Mattapallil, Daniel C. Douek, Brenna Hill, Yoshiaki Nishimura, Malcolm Martin, Mario Roederer, Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection Nature. ,vol. 434, pp. 1093- 1097 ,(2005) , 10.1038/NATURE03501
Beulah P Sabundayo, Julie H McArthur, Susan J Langan, Joel E Gallant, Joseph B Margolick, High frequency of highly active antiretroviral therapy modifications in patients with acute or early human immunodeficiency virus infection. Pharmacotherapy. ,vol. 26, pp. 674- 681 ,(2006) , 10.1592/PHCO.26.5.674
Lisa Demeter, Ronald J Bosch, Evgenia Aga, Carla Pettinelli, Martin Hirsch, Mary Vogler, Ana Martinez, Susan Little, Elizabeth Connick, Paul Volberding, Antiretroviral therapy in acute and recent HIV infection: a prospective multicenter stratified trial of intentionally interrupted treatment. AIDS. ,vol. 23, pp. 1987- 1995 ,(2009) , 10.1097/QAD.0B013E32832EB285
B. F. Keele, E. E. Giorgi, J. F. Salazar-Gonzalez, J. M. Decker, K. T. Pham, M. G. Salazar, C. Sun, T. Grayson, S. Wang, H. Li, X. Wei, C. Jiang, J. L. Kirchherr, F. Gao, J. A. Anderson, L.-H. Ping, R. Swanstrom, G. D. Tomaras, W. A. Blattner, P. A. Goepfert, J. M. Kilby, M. S. Saag, E. L. Delwart, M. P. Busch, M. S. Cohen, D. C. Montefiori, B. F. Haynes, B. Gaschen, G. S. Athreya, H. Y. Lee, N. Wood, C. Seoighe, A. S. Perelson, T. Bhattacharya, B. T. Korber, B. H. Hahn, G. M. Shaw, Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 7552- 7557 ,(2008) , 10.1073/PNAS.0802203105
Andrew J. McMichael, Persephone Borrow, Georgia D. Tomaras, Nilu Goonetilleke, Barton F. Haynes, The immune response during acute HIV-1 infection: clues for vaccine development Nature Reviews Immunology. ,vol. 10, pp. 11- 23 ,(2010) , 10.1038/NRI2674
Remonie Seng, Cécile Goujard, Loïc Desquilbet, Martine Sinet, Christine Rouzioux, Christiane Deveau, Faroudy Boufassa, Jean-François Delfraissy, Laurence Meyer, Alain Venet, ANRS PRIMO and SEROCO Study Groups, Rapid CD4+ cell decrease after transient cART initiated during primary HIV infection (ANRS PRIMO and SEROCO cohorts). Journal of Acquired Immune Deficiency Syndromes. ,vol. 49, pp. 251- 258 ,(2008) , 10.1097/QAI.0B013E318189A739