Surface modification of solid lipid nanoparticles for oral delivery of curcumin: Improvement of bioavailability through enhanced cellular uptake, and lymphatic uptake
作者： Jong-Suep Baek , Cheong-Weon Cho
DOI: 10.1016/J.EJPB.2017.04.013
关键词:
摘要: Curcumin has been reported to exhibit potent anticancer effects. However, poor solubility, bioavailability and stability of curcumin limit its in vivo efficacy for the cancer treatment. Solid lipid nanoparticles (SLN) are a promising delivery system enhancement hydrophobic drugs. burst release drug from SLN acidic environment limits usage as oral system. Hence, we prepared N-carboxymethyl chitosan (NCC) coated curcumin-loaded (NCC-SLN) inhibit rapid enhance bioavailability. The NCC-SLN exhibited suppressed simulated gastric fluid while sustained was observed intestinal fluid. Furthermore, increased cytotoxicity cellular uptake on MCF-7 cells. lymphatic were found be 6.3-fold 9.5-fold higher than that solution, respectively. These results suggest could an efficient curcumin.
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