Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.

摘要: Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness TAS2R disease models are lacking. Here we to determine on features asthma. Further, elucidated a mechanism which mitigate was induced mice using intranasal house dust mite or aerosol ova-albumin challenge, chloroquine quinine were tested both prophylactic treatment Allergen challenge resulted inflammation as evidenced increased immune cells infiltration release cytokines chemokines lungs, significantly attenuated treated mice. including smooth muscle mass, extracellular matrix deposition pro-fibrotic signaling, also prevented accumulation development AHR Mechanistic human neutrophils demonstrated that inhibition cell chemotaxis key blocked allergic exerted anti-asthma effects. Our comprehensive establish mitigating multiple