摘要: Publisher Summary Fat-soluble riboflavin derivatives are synthesized by esterifying alcoholic hydroxyl groups in the ribitol moiety of with some carboxylic acid. This chapter discusses fat-soluable riboflavin. The synthesis modifies properties without losing intactness structure isoalloxazine nucleus solubility is markedly changed esterification; esters obtained soluble organic solvents. A noticeable solvent effect found absorption and fluorescence emission spectra these derivatives. observed results useful interpreting environmental change surrounding flavin coenzyme upon complex formation apoprotcin further substrate or substitute. For synthesizing acyl riboflavin, reagents such as an acid chloride anhydride effectively used. Three examples synthetic procedures fat-soluble described tetrapalmitate, tetrabutyrate, tetranicotinate. physicochemical also discussed.
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sci-hub.se 参考文章(17)
V. Massey, T. Hofmann, Graham Palmer, The relation of function and structure in lipoyl dehydrogenase. Journal of Biological Chemistry. ,vol. 237, pp. 3820- 3828 ,(1962) , 10.1016/S0021-9258(19)84528-3
AKIRA KOTAKI, KEIICHI KATO, MISAO OKUMURA, TORAO SAKURAI, KUNIO YAGI, Studies on riboflavin tetranicotinate. II. Some physiological and pharmacological tests. The Journal of vitaminology. ,vol. 14, pp. 253- 269 ,(1968) , 10.5925/JNSV1954.14.253
KUNIO YAGI, JUN OKUDA, MISAO KOBAYASHI, STUDIES ON FATTY ACID ESTERS OF FLAVINS. III. NUTRITIONAL AND ARIBOFLAVINOSIS-CURING EFFECTS. The Journal of vitaminology. ,vol. 9, pp. 168- 176 ,(1963) , 10.5925/JNSV1954.9.168
KUNIO YAGI, JUN OKUDA, SOICHI NIWA, YOSHIKO YAMAMOTO, Studies on fatty acid esters of flavins. II. Hydrolysis of fatty acid esters of riboflavin by pancreatic lipase and digestive juice. The Journal of vitaminology. ,vol. 7, pp. 281- 286 ,(1961) , 10.5925/JNSV1954.7.281
KUNIO YAGI, JUN OKUDA, A. A. DMITROVSKII, CHEMICAL SYNTHESIS OF RIBOFLAVIN PALMITATE Journal of Biochemistry. ,vol. 48, pp. 621- 622 ,(1960) , 10.1093/OXFORDJOURNALS.JBCHEM.A127210
AKIRA KOTAKI, MAKOTO NAOI, KUNIO YAGI, A possible interpretation of the binding of D-amino acid oxidase with benzoate. Journal of Biochemistry. ,vol. 59, pp. 625- 628 ,(1966) , 10.1093/OXFORDJOURNALS.JBCHEM.A128353
Luigi Casola, Philip E. Brumby, Vincent Massey, The Reversible Conversion of Lipoyl Dehydrogenase to an Artifactual Enzyme by Oxidation of Sulfhydryl Groups Journal of Biological Chemistry. ,vol. 241, pp. 4977- 4984 ,(1966) , 10.1016/S0021-9258(18)99659-6
KUNIO YAGI, JUN OKUDA, A. A. DMITROVSKII, RIKUKO HONDA, TOSHIRO MATSUBARA, Studies on fatty acid esters of flavins. I. Chemical syntheses of fatty acid esters of riboflavin. The Journal of vitaminology. ,vol. 7, pp. 276- 280 ,(1961) , 10.5925/JNSV1954.7.276
Kunio Yagi, Nobuko Ohishi, Makoto Naoi, Akira Kotaki, Solvent effect on fluorescence of fat-soluble riboflavin derivatives Archives of Biochemistry and Biophysics. ,vol. 134, pp. 500- 505 ,(1969) , 10.1016/0003-9861(69)90311-7
KUNIO YAGI, YOSHIKO YAMAMOTO, IKUO NISHIGAKI, HIROSHI OHKAWA, Direct absorption of riboflavin tetrabutyrate through digestive canal. The Journal of vitaminology. ,vol. 16, pp. 247- 248 ,(1970) , 10.5925/JNSV1954.16.247