Application of GC-MS with a SPME and thermal desorption technique for determination of dimethylamine and trimethylamine in gaseous samples for medical diagnostic purposes.
作者： Beata Wzorek , Paweł Mochalski , Ireneusz Śliwka , Anton Amann
DOI: 10.1088/1752-7155/4/2/026002
关键词:
摘要: Biogenic amines are interesting compounds which may be of use for medical diagnosis or therapeutic monitoring. The present paper deals with the problems that occur concentration determination dimethylamine (DMA) and trimethylamine (TMA). These in breath people suffering from renal disease. measurement trace concentrations requires application suitable analytical methods during sampling, storage preconcentration. This is particularly so due to their polar basic properties. In this paper, solid phase microextraction (SPME) thermal desorption (TD) subsequent by GC-MS discussed. For DMA, preconcentration SPME did not give satisfactory results. TMA analysed using an LOD 1.5 ppb. Thermal Tenax as adsorbing material allows reliable (LOD = 0.5 ppb) DMA 4.6 ppb). cannot stored reliably Tedlar bags longer on (with TD) does good repeatability TMA, can done bags, best results latter being achieved Flex Foil bags.
harvard.edu
sci-hub.se 参考文章(42)
Anton Amann, David Smith, Breath analysis for clinical diagnosis and therapeutic monitoring World Scientific Publishing. ,(2005)
Steven H. Zeisel, Kerry Ann DaCosta, Increase in Human Exposure to Methylamine Precursors of N-Nitrosamines after Eating Fish Cancer Research. ,vol. 46, pp. 6136- 6138 ,(1986)
A.M. Asatoor, M.L. Simeshoff, The origin of urinary dimethylamine. Biochimica et Biophysica Acta. ,vol. 111, pp. 384- 392 ,(1965) , 10.1016/0304-4165(65)90048-6
Nenoo Rawal, Ramesh Rajpurohit, Michael A. Lischwe, Kenneth R. Williams, Woon Ki Paik, Sangduk Kim, Structural specificity of substrate for S-adenosylmethionine:protein arginine N-methyltransferases. Biochimica et Biophysica Acta. ,vol. 1248, pp. 11- 18 ,(1995) , 10.1016/0167-4838(94)00213-Z
Magdalena Ligor, Tomasz Ligor, Amel Bajtarevic, Clemens Ager, Martin Pienz, Martin Klieber, Hubert Denz, Michael Fiegl, Wolfgang Hilbe, Wolfgang Weiss, Peter Lukas, Herbert Jamnig, Martin Hackl, Boguslaw Buszewski, Wolfram Miekisch, Jochen Schubert, Anton Amann, None, Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry. Clinical Chemistry and Laboratory Medicine. ,vol. 47, pp. 550- 560 ,(2009) , 10.1515/CCLM.2009.133
Kristine Chobanyan, Anja Mitschke, Frank-Mathias Gutzki, Dirk O. Stichtenoth, Dimitrios Tsikas, Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC–MS and GC–tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization mode ☆ Journal of Chromatography B. ,vol. 851, pp. 240- 249 ,(2007) , 10.1016/J.JCHROMB.2007.03.006
Leiliane Coelho A. Amorim, Zenilda de L. Cardeal, Breath air analysis and its use as a biomarker in biological monitoring of occupational and environmental exposure to chemical agents Journal of Chromatography B. ,vol. 853, pp. 1- 9 ,(2007) , 10.1016/J.JCHROMB.2007.03.023
Kerry-Ann daCosta, J.James Vrbanac, Steven H. Zeisel, The measurement of dimethylamine, trimethylamine, and trimethylamine N-oxide using capillary gas chromatography-mass spectrometry. Analytical Biochemistry. ,vol. 187, pp. 234- 239 ,(1990) , 10.1016/0003-2697(90)90449-J
T Ligor, M Ligor, A Amann, C Ager, M Bachler, A Dzien, B Buszewski, The analysis of healthy volunteers' exhaled breath by the use of solid-phase microextraction and GC-MS. Journal of Breath Research. ,vol. 2, pp. 046006- ,(2008) , 10.1088/1752-7155/2/4/046006
Frank Sacher, Steffen Lenz, Heinz-Jürgen Brauch, Analysis of primary and secondary aliphatic amines in waste water and surface water by gas chromatography-mass spectrometry after derivatization with 2,4-dinitrofluorobenzene or benzenesulfonyl chloride Journal of Chromatography A. ,vol. 764, pp. 85- 93 ,(1997) , 10.1016/S0021-9673(96)00868-0