Methods of treating hormone-related conditions using cyclothiocarbamate derivatives
作者： Eugene Anthony Terefenko , Richard Craig Winneker , Gary S. Grubb , Puwen Zhang , Diane Deborah Harrison
DOI:
关键词:
摘要: The present invention provides methods of inducing contraception which includes delivering to a female composition containing compound formula I or II, tautomers thereof, in regimen involves one more selective estrogen receptor modulator, wherein is: and R 1 -R 5 Q are defined as described herein. Methods providing hormone replacement therapy for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome is provided modulator also described.
lens.org 参考文章(10)
Karl Theodor Kraemer, Manfred Bohn, Compositions for Topical Application Having Androgenic Actions ,(1999)
Christopher Paul Miller, Michael Jay Gast, Anti-estrogen plus progestin containing oral contraceptives ,(1998)
Vladimir Petrow, Leon Lack, Method of treating androgen-related disorders ,(1981)
Puwen Zhang, Eugene A. Terefenko, Andrew Fensome, Zhiming Zhang, Yuan Zhu, Jeffrey Cohen, Richard Winneker, Jay Wrobel, John Yardley, Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines. Bioorganic & Medicinal Chemistry Letters. ,vol. 12, pp. 787- 790 ,(2002) , 10.1016/S0960-894X(02)00025-2
Puwen Zhang, Eugene A. Terefenko, Andrew Fensome, Jay Wrobel, Richard Winneker, Zhiming Zhang, Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists. Bioorganic & Medicinal Chemistry Letters. ,vol. 13, pp. 1313- 1316 ,(2003) , 10.1016/S0960-894X(03)00128-8
Eugene A. Terefenko, Christopher M. Tegley, James P. Edwards, Puwen Zhang, Jay E. Wrobel, Mark A. Collins, Todd K. Jones, Andrew Fensome, Lin Zhi, Cyclothiocarbamate derivatives as progesterone receptor modulators ,(2000)
Edward G. Melenski, Christopher M. Tegley, Marci C. Koko, James P. Edwards, Puwen Zhang, Jay E. Wrobel, Todd K. Jones, Andrew Fensome, Lin Zhi, Thio-oxindole derivatives ,(2002)
Valerie A. Mackner, James P. Edwards, Jay E. Wrobel, Mark A. Collins, Todd K. Jones, Lin Zhi, Christopher M. Tegley, Cyanopyrroles as progesterone receptor agonists ,(2000)
Roger M Freidinger, Peter D Williams, Ian M Bell, Benzoxazinone oxytocin receptor antagonists ,(1997)
Eugene A. Terefenko, James P. Edwards, Puwen Zhang, Jay E. Wrobel, Todd K. Jones, Andrew Fensome, Lin Zhi, Horace Fletcher, Christopher M. Tegley, Cyclocarbamate derivatives as progesterone receptor modulators ,(2000)