The pyrrole approach toward the synthesis of fully functionalized cup-shaped molecules.
作者： Cristiano Zonta , Fabrizio Fabris , Ottorino De Lucchi
DOI: 10.1021/OL047569F
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摘要: A novel method for the synthesis of new highly functionalized cyclotrimers is described. The consists an original β-dibromosubstituted pyrroles, metalation, cycloaddition, and cyclotrimerization. sequence compatible with common functional groups allows construction cup-shaped molecules both at upper bottom rim. This feature makes newly formed structures useful scaffolds development supramolecular receptors.
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