Effects of epidermal growth factor, estrogen, and progestin on DNA synthesis in mammary cells in vivo are determined by the developmental state of the gland

摘要: Estrogen (E), progesterone (P), and epidermal growth factor (EGF) are involved in the development of normal mammary gland. While studies have been carried out to investigate vivo effects EGF immature gland, nothing is known about or its potential interactions with E and/or P adult The present were undertaken EGF, E, on cell proliferation immature, peripubertal vs. adult, sexually mature mice. We found that promotes epithelial stromal both glands. In end bud epithelium most responsive proliferative there no apparent interaction between P. contrast, gland adds E+P ductal resulting more extensive sidebranching. Thus these results demonstrate developmental state determines nature extent development. © 1993 Wiley-Liss, Inc.