Chemical aspects of acylfulvene bioactivation to a cytotoxic reactive intermediate.
作者： Kathryn Elizabeth Pietsch
DOI:
关键词:
摘要: University of Minnesota M.S. thesis. December 2009. Major: Medicinal Chemistry. Advisor: Professor Shana J. Sturla, Ph.D. 1 computer file (PDF); iv, 34 pages.
参考文章(19)
Gerhard Erker, Rainer Nolte, Rainer Aul, Stephan Wilker, Carl Krueger, Ralf Noe, Cp-substituent additivity effects controlling the stereochemistry of the propene polymerization reaction at conformationally unrestricted (Cp-CHR1R2)2ZrCl2/methylalumoxane catalysts Journal of the American Chemical Society. ,vol. 113, pp. 7594- 7602 ,(1991) , 10.1021/JA00020A022
Jay S. Siegel, Surk-sik Moon, Medgar M. Moya, Trevor C. McMorris, Michael J. Kelner, Raj K. Chadha, Structure and reactivity of illudins Tetrahedron. ,vol. 45, pp. 5433- 5440 ,(1989) , 10.1016/S0040-4020(01)89489-8
W. R. Jackson, A. Zurqiyah, 985. The occurrence of 1,2- or 1,4-addition in the reduction of some αβ-unsaturated ketones with metal hydrides J. Chem. Soc.. ,vol. 0, pp. 5280- 5287 ,(1965) , 10.1039/JR9650005280
Jiachang Gong, V. G. Vaidyanathan, Xiang Yu, Thomas W. Kensler, Lisa A. Peterson, Shana J. Sturla, Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agent. Journal of the American Chemical Society. ,vol. 129, pp. 2101- 2111 ,(2007) , 10.1021/JA0665951
Trevor C. McMorris, Anissa N. Elayadi, Jian Yu, Michael J. Kelner, Metabolism of antitumor acylfulvene by rat liver cytosol. Biochemical Pharmacology. ,vol. 57, pp. 83- 88 ,(1999) , 10.1016/S0006-2952(98)00273-1
Trevor C McMorris, Discovery and development of sesquiterpenoid derived hydroxymethylacylfulvene: a new anticancer drug. Bioorganic & Medicinal Chemistry. ,vol. 7, pp. 881- 886 ,(1999) , 10.1016/S0968-0896(99)00016-4
Kent S. Gates, An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals Chemical Research in Toxicology. ,vol. 22, pp. 1747- 1760 ,(2009) , 10.1021/TX900242K
Jiachang Gong, James F. Neels, Xiang Yu, Thomas W. Kensler, Lisa A. Peterson, Shana J. Sturla, Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity. Journal of Medicinal Chemistry. ,vol. 49, pp. 2593- 2599 ,(2006) , 10.1021/JM051104T
James F. Neels, Jiachang Gong, Xiang Yu, Shana J. Sturla, Quantitative Correlation of Drug Bioactivation and Deoxyadenosine Alkylation by Acylfulvene Chemical Research in Toxicology. ,vol. 20, pp. 1513- 1519 ,(2007) , 10.1021/TX7001756
T. C. McMorris, M. J. Kelner, W. Wang, M. A. Diaz, L. A. Estes, R. Taetle, Acylfulvenes, a new class of potent antitumor agents. Cellular and Molecular Life Sciences. ,vol. 52, pp. 75- 80 ,(1996) , 10.1007/BF01922420