Comparative Transcriptome Analysis of Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV in Susceptible and Near-Isogenic Resistant Strains

摘要: Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the primary pathogens causing severe economic losses in sericulture. However, molecular mechanism silkworm resistance to BmNPV remains largely unknown. Here, recurrent parent P50 (susceptible strain) and near-isogenic line BC9 (resistance were used a comparative transcriptome study examining response infection with BmNPV. A total 14,300 unigenes obtained from two different resistant strains; these, 869 differentially expressed genes (DEGs) identified after comparing four transcriptomes. Many DEGs associated protein metabolism, cytoskeleton, apoptosis may be involved host infection. Moreover, some immunity related also altered following Specifically, removing genetic background individual immune stress genes, 22 found potentially repressing These transport, virus replication, intracellular innate immune, apoptosis. Our provided an overview laid foundation for controlling future.