Inhibitors of endo-exonuclease activity for treating cancer
作者： Terry Chow , Chiaoli Yeh , David Griller , Leonard Yuen
DOI:
关键词:
摘要: The present invention relates to the treatment of cancer with compounds that inhibit activity endo-exonuclease. Endo-exonuclease has been shown be necessary for repair damaged DNA. Compounds endo-exonuclease have particularly effective treating when used in combination drugs induce DNA breaks such as cisplatin and mitomycin C. These a synergistic effect inhibiting tumour growth. includes pharmaceutical compositions growth comprising compound inhibits activity. preferably include breaks. methods these uses treat cancer. preferred low toxicity. One is pentamidine. also method diagnosing monitoring its progression. This aspect involves isolating serum from patient; measuring concentration said determining whether above predetermined mean.
lens.org 参考文章(52)
Richard R. Tidwell, Christine C. Dykstra, David Boykin, Methods of treating retroviral infection and compounds useful therefor ,(1997)
Richard R. Tidwell, Christine C. Dykstra, Arvind Kumar, Jaroslaw Spychala, W. David Wilson, David W. Boykin, Bijan P. Das, Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor ,(1994)
Michael A. Resnick, Miroslav Radman, System for isolating and producing new genes, gene products and DNA sequences ,(1990)
Kevin J. Scanlon, Lawrence C. Sowers, Use of certain nucleoside analogs to attenuate cancer cell resistance to DNA damaging chemotherapy ,(1989)
D. Dennison, I. Z. Tuan, Daniel J Weisdorf, Pneumocystis carinii pneumonitis following bone marrow transplantation. Bone Marrow Transplantation. ,vol. 10, pp. 267- 272 ,(1992)
Srinivasan Varadarajan, Hikmat A. Musallam, Babu J. Mavunkel, Govindarajan Manikumar, Atanu Biswas, Richard J. Sundberg, Daniel J. Dahlhausen, Compounds exhibiting anti-parasitic activity and a method for their use ,(1987)
Michael A. Resnick, Torston Nilsson-Tillgren, Sensitive yeast genetic system for identifying agents causing double-stranded DNA damage ,(1992)
Shiro Shibayama, Daikichi Fukushima, Hideaki Tada, Polypeptide, cDNA encoding the same and use of them ,(1998)
John M. Gaithersburg Greene, Craig A. Laytonsville Rosen, Human tissue inhibitor of metalloproteinase- 4 ,(1994)
Edward L. Perkins, Michael A. Resnick, Terry Chow, Chimeric protein that has a human Rho motif and deoxyribonuclease activity ,(1993)