Rhodium catalyzed chelation-assisted C-H bond functionalization reactions

摘要: Over the last several decades, researchers have achieved remarkable progress in field of organometallic chemistry. The development metal-catalyzed cross-coupling reactions represents a paradigm shift chemical synthesis, and today synthetic chemists can readily access carbon–carbon carbon–heteroatom bonds from vast array starting compounds. Although we cannot understate importance these methods, required prefunctionalization to carry out adds cost reduces availability reagents.The use C–H bond activation lieu has presented tantalizing alternative classical reactions. Researchers met challenges selectivity reactivity associated with functionalization an explosion creative advances substrate catalyst design. Literature reports on based steric effects, acidity, electronic directing group effects are n...