The Effects of Hammer Pressure on Cellular Response in a Porcine Heart Valve Tissue
作者： Jason P. Haley , Hadi Mohammadi , Derek R. Boughner
DOI: 10.1007/S10558-010-9101-4
关键词:
摘要: Our objective was to design, develop, characterize and validate a prototype device for testing the response of aortic valve tissue impact forces. With each cardiac cycle, valve, on closure, is subjected substantial force ability valvular interstitial cells withstand such forces without apoptosis has not been examined. aim correlate with apoptosis, identifying latter using terminal transferase dUTP nick end-labelling (Tunel) assay. our drop tower we created reproducible heart resulting in cellular trauma. The reliability tester design were verified results showed that normal can more than 30× greater physiological which normally exposed. This provides wide safety margin indicates bioengineered should have similar properties if it physiologic long term.
springer.com
sci-hub.se 参考文章(21)
Y.S. Morsi, I.E. Birchall, F.L. Rosenfeldt, Artificial aortic valves: an overview. International Journal of Artificial Organs. ,vol. 27, pp. 445- 451 ,(2004) , 10.1177/039139880402700602
RU Repo, JB Finlay, Survival of articular cartilage after controlled impact Journal of Bone and Joint Surgery, American Volume. ,vol. 59, pp. 1068- 1076 ,(1977) , 10.2106/00004623-197759080-00012
J. Bryan Finlay, R. U. Repo, Instrumentation and Procedure for the Controlled Impact of Articular Cartilage IEEE Transactions on Biomedical Engineering. ,vol. BME-25, pp. 34- 39 ,(1978) , 10.1109/TBME.1978.326375
A Negoescu, C Guillermet, P Lorimier, E Brambilla, F Labat-Moleur, Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity. Biomedicine & Pharmacotherapy. ,vol. 52, pp. 252- 258 ,(1998) , 10.1016/S0753-3322(98)80010-3
Amedeo Columbano, CELL-DEATH - CURRENT DIFFICULTIES IN DISCRIMINATING APOPTOSIS FROM NECROSIS IN THE CONTEXT OF PATHOLOGICAL PROCESSES IN-VIVO Journal of Cellular Biochemistry. ,vol. 58, pp. 181- 190 ,(1995) , 10.1002/JCB.240580207
Georg N. Duda, Miriam Eilers, Lawrence Loh, Jan E. Hoffman, Max K????b, Klaus Schaser, Chondrocyte death precedes structural damage in blunt impact trauma. Clinical Orthopaedics and Related Research. ,vol. 393, pp. 302- 309 ,(2001) , 10.1097/00003086-200112000-00035
Eric A Talman, Derek R Boughner, Effect of altered hydration on the internal shear properties of porcine aortic valve cusps. The Annals of Thoracic Surgery. ,vol. 71, ,(2001) , 10.1016/S0003-4975(01)02546-2
M. I. Ionescu, B. C. Pakrashi, D. A. S. Mary, I. T. Bartek, G. H. Wooler, Replacement of heart valves with frame-mounted tissue grafts. Thorax. ,vol. 29, pp. 56- 67 ,(1974) , 10.1136/THX.29.1.56
R.N. Trubshaw, Resonance and signal conditioning in instrumented impact testing Polymer Testing. ,vol. 6, pp. 387- 401 ,(1986) , 10.1016/0142-9418(86)90044-9
Matthew W. Weston, Ajit P. Yoganathan, Biosynthetic activity in heart valve leaflets in response to in vitro flow environments. Annals of Biomedical Engineering. ,vol. 29, pp. 752- 763 ,(2001) , 10.1114/1.1397794