EFFICACY OF POST-EXPOSURE PROPHYLAXIS IN INFANTS BORN TO HBSAG POSITIVE MOTHERS IN IRAN; IS IT AUTHENTIC?

摘要: Background: Hepatitis B infection is a universal concern. This can lead to chronic liver disease and hepatocellular carcinoma. Neonates born HBsAg-positive mothers are at high risk of hepatitis virus (HBV) infection, especially for HBeAg-positive or neonates who have not received immunoglobulin (HBIg) HBV vaccines. Objectives: The aim this study was evaluate the efficacy post-exposure prophylaxis in these infants prevent infection. Patients Methods: Thirty-eight between September 2006 2013 were followed. investigation evaluated whether standard prevention protocol neonatal transmission including HBIg birth receiving three doses vaccine 2 6 months age performed, followed by post-vaccination tests (evaluation HBsAg HBsAb titer 9 18 age) determine subsequent ≥ 10 considered as criterion effectiveness procedure. acquired data analyzed using SPSS software (Version 18). results reported descriptive tabulations. Results: Ninety seven percent (97%) hospital. Generally, all them first, second third birth, months, after respectively. Information 35 infected with 38 available. mean 30.3 years. indicated that 20% HBeAg positive. positive one (2.6%) infant an mother. Around 94% infants’ titers 10, 5.8% non-responders. Conclusions: vertical program used population Tehran, which had appropriate sample size, effective. Additional be useful raising immunoprophylaxis Also, emphasis must set on testing.