Chapter 2 Biomechanics of Leukocyte and Endothelial Cell Surface

摘要: Publisher Summary Human leukocytes—including neutrophils, lymphocytes, and monocytes—are the major immune cells within blood. Leukocytes travel around human body through circulatory vessels that are lined with Endothelial (ECs). When they leave blood, leukocytes roll on ECs first. This is due, in part, to weak adhesive interactions mediated mainly by selectins both ECs. adhesion, coupled force torque imposed leukocyte blood flow, yields a consecutive series of jerky motion leukocyte, often coined “rolling.” Neutrophil lymphocyte rolling essential for their immunological functions, whereas monocyte critical its arrest vascular wall invasion into aortic intima. Leukocyte endothelium first step migration sites infection, injury, or atherosclerotic lesions. Unstable impairs effective neutrophil recruitment infected tissues renders beings defenseless against invading microorganisms, resulting diseases, such as adhesion deficiency syndrome. On other hand, stable infiltration intima initiates exacerbates cardiovascular atherosclerosis. Elucidating mechanisms underlie can pave way toward therapeutic amelioration maladies. However, complex dynamic process concertedly molecules expressed ECs, shear stress due mechanical properties A complete understanding requires thorough knowledge all these areas. chapter discusses recent advances gained biomechanics endothelial cell surface, well impact rolling.