Synthesis and In vitro evaluation of the phenylboric acid derivative entrapped lipiodol in boron neutron capture therapy for hepatoma

摘要: Background Hepatoma, a common cancer in Taiwan, responds poorly to conventional therapies. Boron neutron capture therapy (BNCT) may provide promising approach for hepatoma therapy. In this study, pharmaceutical composition, phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol), was synthesized and characterized. vitro study used evaluation of PBAD-lipiodol the BNCT hepatoma. Materials methods alpha Track observation identify boron compound TLC plate evidence uniform distribution PBAD-lipiodol. Inductively coupled plasma-atomic emission spectroscopy activation analysis were determine concentrations lipiodol, respectively. Human HepG2 cells experiments. A Nomarski optical microscope investigate uptake globules individual cells. Results stable human serum. The source, PBAD, uniformly distributed Many internalized retained cells, concentration reached 269 ppm after 72 hours treatment. Conclusion studies revealed that could deliver therapeutically effective amount PBAD as source is potential new drug