Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice.

摘要: The neuroleptic responsive (NR) and nonresponsive (NNR) selected lines of mice differ more than 10-fold in the ED50 for catalepsy induced by a wide variety neuroleptics with high dopamine D2/D1 receptor activity ratio, e.g., haloperidol. NR NNR also significantly D2 somatodendritic density; within substantia nigra zona compacta ventral tegmental area, increases line are on average 33 48%, respectively. We now report that has higher number neurons midrostral to midcaudal aspect compacta. Within this region, increase cell was 41%. In contrast these data, there no difference between area. Thus, midbrain density can only be accounted part an neurons. Although increased line, terminals caudate-putamen as estimated [3H] mazindol technique modestly but (8%) line. differed cholinergic had rostral caudate-putamen. Overall, data illustrate selective breeding response yielded significant differences both dopaminergic systems basal ganglia.